MIF and colorectal cancer: From these data, we found that the downregulation ratio (the KD/NC ratio) of macrophage migration inhibitory factor (MIF) is 0.6344 (p value = 0.00025) and more importantly, MIF has been known to be involved in EMT process, colorectal cancer progression and metastasis and phenotypic polarization of macrophages [30–32, 35–38].