The study of Hara-Chikuma M et al. demonstrated that AQP3-facilitated H2O2 transport was the precondition of NF-κB activation in KCs participating in the acceleration of psoriasis; In AQP3 knockout mice AQP3 (-/-), IL-23-mediated psoriasiform skin inflammation was reduced [58]. This evidence concerns the gene NFKB1 and dry eye syndrome.