Young CN et al. found that the crucial psoriatic cytokine TNF-α could stimulate the activation of the mTOR-NF-κB pathway by ROS generation and ultimately production of inflammatory cytokines in KCs to initiate and maintain the progression of psoriasis; these ROS-induced cytokines could be attenuated by antioxidant enzyme and catalase, including taurine and N-acetyl-cysteine [28]. The gene discussed is CAT; the disease is psoriasis.