STAT3, as an essential transcription factor, leads to the production of many cytokines in inflammatory processes of KCs [43, 44], which in turn not only have an impact on disturbing the oxidant-antioxidant system but also recruiting a more deal of immune cells into the skin lesions to perpetuate a positive feedback inflammatory loop and remodeling extracellular matrix [28, 36]. This evidence concerns the gene STAT3 and dry eye syndrome.