CYBB and rheumatoid arthritis: It is admitted that the major endogenous enzymatic sources of O2 and H2O2 are transmembrane NADPH oxidases and NADPH oxidase 2 complexes (NOX2) complex-generated ROS can participate in regulating the metabolism and oxidation-reduction signaling pathways of macrophages and neutrophils involved in chronic inflammation, such as mannan-induced Ps and PsA (MIP), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [7].