There is mounting evidence of NETs formation at obvious risk of autoimmune diseases, an inflammatory neutrophil subset with characteristics of aged CD10negCD16lowCD11blow neutrophils appeared in lesional skin and circulation of psoriasis and these aged neutrophils increased IL-17 expression by T cells in a NETosis-dependent way [91]; immature CD10negCD16negCD11bneg/low neutrophils from patients detected a higher ROS level under TNF-α plus f-MLF stimulation as compared with those of healthy controls [91]. This evidence concerns the gene IL17A and psoriasis.