TBCE and psoriasis 14, pustular: Meanwhile, these stressed neutrophils produce weblike NETs under ROS-induced respiratory burst, and the release of MPO, elastase and hydrolase from NETs are known to transform inactive precursors of the IL-1β and IL-36 family released from KCs into more biologically active mature bodies, leading to the characteristic pro-inflammatory imbalance of the IL-36 autocrine and autoinflammatory circuits in generalized pustular psoriasis [87, 89, 90].