In psoriasis, SIRT1 has been reported as a vital detoxifier of ROS-mediated redox signaling pathways, including MAPK, NF-κB, and STAT3, with downregulation of psoriatic inflammatory cytokines, suppression of keratinocyte hyperproliferation, and inhibition of angiogenesis [32, 46–50]. The gene discussed is NFKB1; the disease is psoriasis.