F2 and hepatocellular carcinoma: Moreover, it is worth noting that other methods for diagnosing HCC through serum diagnostic markers, such as exosomal DNA containing the TP53 gene mutation [32], phenylalanyl-tryptophan [33], miRNAs, such as miR-10b [34], prothrombin induced by vitamin K deficiency or antagonist-II [35], lncRNA-D16366[36], des-gamma-carboxyprothrombin [37], and dickkopf-1 [38], etc., have been documented.