By contrast, the ROC curve analysis for G-test, AFP, and AAR among HCC versus CH patients found that AAR had the greatest diagnostic ability, with AUC of 0.850 (0.762–0.915), compared to 0.786 (0.690–0.864) and 0.652 (0.547–0.746) for, respectively, G-test and AFP (Fig. 2B). This evidence concerns the gene AFP and cyclic hematopoiesis.