MLH1 and neoplasm: Univariate Cox analysis revealed that higher signature score, tumor location, total resection, T stage, N stage, MLH1 positivity, diffuse Lauren type, poor differentiation, ACRG subtype (especially EMT), absent chemotherapy, mesenchymal phenotype, and Borrmann type IV were risk factors for OS and/or DFS either in the training-validation dataset (Table 5A) or in the complete ACRG cohort (Table 5B).