Likewise, injection of ApoSQ inhibited the activation of migration- and invasion-related signaling pathways, including the Smad2/3, FAK, ERK, and Akt pathways, as well as the protein expression of MMP2 and MMP12 in CD326+ tumor cells (Fig. 8i and Supplementary Fig. S12g). This evidence concerns the gene SMAD2 and neoplasm.