Consistent with our in vitro findings, injection of ApoSQ-CAF CM inhibited the migration and invasion of CD326+ tumor cells and Thy1+ CAFs, whereas injection of WISP-1-immunodepleted ApoSQ-CAF CM did not have inhibitory effects (Fig. 9k, l and Supplementary Fig. S13a, b). This evidence concerns the gene EPCAM and neoplasm.