Injection of ApoSQ-CAF CM downregulated the expression of genes (by >2 fold) involved in tumor progression and invasion (fifteen genes, including MMP2, Cdh6, Smad2, Kras, and Igf1) and upregulated the expression of genes (by >2 fold) involved in suppression of tumor progression and invasion (eight genes, including Cdkn2a, Rorβ, and Ctnna1) in isolated CD326+ tumor cells (Fig. 9i). The gene discussed is SMAD2; the disease is neoplasm.