TNF and rheumatoid arthritis: The top five regulators for the RA-TNF/NP groups were TNF (p-value 1.70 × 10–54), IFN-Ƴ (p-value 2.64 × 10–48), IL1B (p-value 3.29 × 10–35), lipopolysaccharide (p-value 56.52 × 10–34) and IFN-α (p-value 2.87 × 10–31), when compared to RA-TNF.