COL4A1 and aneurysm: FRAT usually presents without systemic association but some patients have presented with different systemic vascular abnormalities, including cerebral aneurysms [20] and hereditary angiopathy with nephropathy, aneurysm, and muscle cramps [21], both of which were associated with COL4A1 mutations; and familial haematuria that was associated with basement membrane abnormalities [22].