Compared with KC mice, KCR mice exhibited a significant reduction in the formation of PanIN lesions of all grades (IA, IB, II, III) at both 6 and 9 months of age (Fig. 4b, c), suggesting RASON is involved in the early stage of KRAS-driven pancreatic tumor initiation. This evidence concerns the gene CLEC4F and pancreatic neoplasm.