Regarding the relationship between various anthropometric, clinical, and biochemical parameters associated with metabolic syndrome (body weight, BMI, waist circumference, SBP, DBP, TC, HDL-C, LDL-C, TG, glucose, HbA1c, insulin and HOMA-R) and the five genera (g_Atopobium, g_Granulicatella, g_Oribacterium, g_Succinivibrio, g_Brachyspira), significant differences between MHO and MUO were shown in a heat map using Spearman's rank correlation coefficient (Fig. 4). Here, INS is linked to metabolic syndrome.