Our findings with more frequent T4 gene cluster carriers in HCs, which is likely imparted by the presence of 3DS1/2DS1 combination in T4 gene cluster, are in contravention of CxT4 predisposing role in head and neck squamous cell carcinoma and colorectal adenocarcinoma reported in our previous studies of the same population75,76. Here, CD4 is linked to colorectal adenocarcinoma.