TLCD1 and metabolic dysfunction-associated steatohepatitis: As the PE fatty acyl chains can be hydrolyzed to provide fatty acid substrates for eicosanoid biosynthesis32, it is plausible that altered hepatic PE composition in Tlcd1/2 DKO mice affects hepatocyte eicosanoid production, leading to reduced NASH development in WD-fed Tlcd1/2 DKO mice compared to controls.