CD4+ T cells serve several critical functions in the antitumor immune response, including recognizing neoantigens that result from tumor-specific mutations7,8, recruiting and activating innate immune cells9–11, directly lysing MHC II positive tumor cells12, and relaying indispensable “help” signals to CD8+ T cells to enhance their antitumor function and memory formation13. This evidence concerns the gene CD8A and neoplasm.