These data correlated with the increased expression of both ETA and ETB in human primary lung cancer cells (Fig. 8E), human lung cancer adenocarcinoma (ADC), lung cancer squamous cell carcinoma tissues (SSC) (Supplementary Fig. 12A) and mouse lung cancer tissues (KRasLA2, LLC1) (Supplementary Fig. 12B). This evidence concerns the gene EDNRA and squamous cell carcinoma.