Along this line, bosentan treatment in naïve (non HSV-TK/Col1 bone marrow transplanted) mice markedly reduced lung tumor growth in three different models of lung cancer: human A549 cells injected into BALB/c nude mice, KRasLA2 oncogenic lung tumor model, and mouse LLC1 cells injected into syngenic wild-type mice also in the absence of exogenous fibrocyte co-injection, which may well indicate the impact of bosentan on endogenous mouse fibrocytes. The gene discussed is TKT; the disease is lung carcinoma.