Importantly, increased accumulation of fibrocytes (CD45+Col1+CCR2+CD44+CD163+CD162+) was observed in tumor tissue of all lung cancer types, including non-small cell lung carcinoma (adenocarcinoma (ADC), adenosquamous cell carcinoma (ADSCC), mucous adenocarcinoma (MADC), papillary adenocarcinoma (PADC), and squamous cell carcinoma (SCC), as compared with healthy lung tissues (Fig. 4A, B). This evidence concerns the gene CD44 and neoplasm.