VWF and cancer: The neighborhood was defined as all cells and was characterized by: 1) the total number of fibrocytes, cancer cells, macrophages, fibroblasts, and endothelial cells in the neighborhood; 2) the number of cells in the neighborhood from each of the following phenotypes: cancer cells (CK+CD45–), fibrocytes (CD163+aSMA-Col1+), endothelial cells (vWF+), macrophages (CD163+Col1-) and fibroblasts (aSMA+Col1+CD163-); 3) as the average distances to fibrocyte of the cellular phenotypes, where the distance was set to 100 μm29,30.