These data correlated with the increased expression of both ETA and ETB in human primary lung cancer cells (Fig. 8E), human lung cancer adenocarcinoma (ADC), lung cancer squamous cell carcinoma tissues (SSC) (Supplementary Fig. 12A) and mouse lung cancer tissues (KRasLA2, LLC1) (Supplementary Fig. 12B). The gene discussed is EDNRB; the disease is lung cancer.