Concordantly, we have demonstrated that CD32-CR T cells recognize CD32-CR putative ligand(s), on MDA-MB-468 and MDA-MB-231 BC cells, resulting in specific CD32 down-regulation and CD107a release consistent with cytotoxic granule exocytosis of T cells in an HLA-independent manner (Alter et al, 2004). This evidence concerns the gene FCGR2C and breast cancer.