Indeed, IL6, a key inflammatory gene, which is up-regulated in patients suffering COVID-19 (Manjili et al, 2020), was up-regulated in the context of SARS-CoV-2 infection (P-value = 6.44 × 10−73, FC = 3.32) but down-regulated in uninfected EXOSC2 edited Calu-3 cells compared with unedited cells (P = 3.45 × 10−10, FC = 0.67, Fig 4C). The gene discussed is IL6; the disease is COVID-19.