Notably we found TOPORS and UBR1 dysregulated in the USH1B organoids (GO:0010498; Figure 4F; Table S4); mutation of the former is a cause of autosomal dominant RP (Chakarova et al., 2007), and the latter promotes rhodopsin protein degradation in the OS via the UPS during retinal inflammation (Ozawa et al., 2008). The gene discussed is TOPORS; the disease is inflammation.