RHO and inflammation: Notably we found TOPORS and UBR1 dysregulated in the USH1B organoids (GO:0010498; Figure 4F; Table S4); mutation of the former is a cause of autosomal dominant RP (Chakarova et al., 2007), and the latter promotes rhodopsin protein degradation in the OS via the UPS during retinal inflammation (Ozawa et al., 2008).