GPC3 and cancer: Mutations in GPC3 cause Simpson-Golabi-Behmel overgrowth syndrome (SGBS), a genetic disorder that presents with visceral and skeletal abnormalities and an increased risk of cancer (Cano-Gauci et al., 1999; Pilia et al., 1996; Tenorio et al., 2014; Veugelers et al., 2000).