The Unc5-GPC3-dependent mechanisms we found in neuroblastoma migration could apply to other disseminating cancers, given that GPC3 is an oncofetal protein expressed by many pediatric solid embryonal tumors (Ortiz et al., 2019) and adult cancers (Li et al., 2018; Shimizu et al., 2019). This evidence concerns the gene GPC3 and neuroblastoma.