For instance, endosomal TLR3 and TLR7, and cytosolic retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) have been shown to sense the DENV RNA early in the infection, thereby leading to the production of type I interferons [12–14]. The gene discussed is IFIH1; the disease is infection.