ABO and Stroke: Both SNPs also had significantly larger effect sizes for all stroke in EOS compared with LOS (ABO rs529565: OR = 0.88 [95% CI: 0.85–0.91] vs 0.96 [95% CI: 0.91–1.00] and ABO rs635634: OR = 1.16 [95% CI: 1.11–1.21] vs 1.05 [95% CI: 1.00–1.10], p-values for interaction = 0.0004 and 0.001, respectively) (eFigure 3, links.lww.com/WNL/C245).