MAPKAPK5 and ischemic stroke: Three of the 29 unique loci associated with EOS in either the transethnic or European-only analysis at subgenome thresholds (i.e., p < 1 × 10−6) were nominally associated with LOS at p < 0.05 (eTables 4 and 5), and one of these, rs115133729 in MAPKAPK5, was strongly associated with LOS (p = 1.30 × 10−7) and has previously been associated with all ischemic stroke in MEGASTROKE Europeans (Cerebrovascular Disease Knowledge Portal, accessed April 16, 2022).