We have also seen, using mice with either a c-Rel gene knockout or with a RelA Thr 505 to Ala mutation (RelAT505A), that both Eμ-Myc/cRel−/− and Eμ-Myc/RelAT505A lymphomas exhibit lower levels of Claspin mRNA and protein expression [18]. The gene discussed is REL; the disease is lymphoma.