Surprisingly, even though Eμ-Myc/RelAT505A lymphomas did not display significant up-regulation of PI3K or AKT activity by western blot, they were still sensitive to GDC-0941 treatment (Figure 3D, Supplementary Figure S7), suggesting that the down-regulation of CHK1 activity we see in these cells [18] creates a dependence on the existing PI3K/AKT activity they possess (Figure 3A, Supplementary Figure S6A). This evidence concerns the gene MYC and lymphoma.