REL and lymphoma: Through analysing our RNA-Seq dataset for the presence of intrinsically up-regulated gene expression signatures in Eμ-Myc/RelAT505A lymphomas, we discovered elevated expression of genes encoding components of the RAC1/RHOA signalling pathway, something also seen in Eμ-Myc/c-Rel−/− lymphomas (Figure 4, Supplementary Figure S8).