To better understand the underlying mechanistic basis that explains the relatively few significant (phospho)protein changes observed in Eμ-Myc/cRel−/− lymphomas in response to treatment with CCT244747, we compared the protein and gene expression profiles of re-implanted WT and Eμ-Myc/cRel−/− lymphomas in the absence of CCT244747 treatment. This evidence concerns the gene MYC and lymphoma.