MYC and lymphoma: Furthermore, ∼75% of the protein level changes (and over 62% of the phosphorylation changes) that were induced in response to Chk1i in the WT Eμ-Myc lymphomas were also observed in the Eμ-Myc/cRel−/− samples with no treatment, suggesting that inhibition of Chk1 with CCT244747 may be working in part by modulating c-Rel-dependent processes (Supplementary Figure S3B,C, Supplementary Data File S1).