In contrast, no effects were seen on Atr, Atrip, Topbp1, Rad17 and Chek1 mRNA levels (Supplementary Figure S8B), with western blot analysis confirming no changes to RAD17, ATRIP and ATR protein levels between WT and RelA T505A lymphoma cells (Supplementary Figure S8C). Here, TOPBP1 is linked to lymphoma.