Related to this manuscript we show elsewhere, also using the Eμ-Myc model of B-cell lymphoma, that deletion of the c-Rel NF-κB subunit results in loss of CHK1 protein, at least in part due to down-regulation of the deubiquitinase USP1 [24]. The gene discussed is CHEK1; the disease is B-cell non-Hodgkin lymphoma.