CLSPN and lymphoma: Furthermore, in normal B cells no difference in Clspn expression was seen between WT and T505A or c-Rel−/− cells (Supplementary Figure S8D), Taken together, this suggests that in Eμ-Myc lymphoma cells, mutation of RelA at T505 or loss of c-Rel results in a failure to induce Clspn mRNA levels in response to DNA replication stress.