Thus, previous studies havedetermined how pioglitazone, a drugof the thiazolidinedione (TZD) family, has demonstrated in severalmurine models to lead to anti-inflammatory and neuroprotective effectsin ALS.18,19 In addition, leptin, which is a polypeptidehormone primarily secreted by adipocytes and regulates energy balanceand food intake in the brain,20,21 has been demonstratedto act as a neuroprotective species reducing the progressive deteriorationof neurological conditions. This evidence concerns the gene LEP and amyotrophic lateral sclerosis.