LEP and amyotrophic lateral sclerosis: Moreover, ithas been observed in some epidemiological and clinical research worksthat altered leptin levels may be implicated in ALS pathogenesis.24 Indeed, recent epidemiological work has associatedALS risk with low altered levels of leptin.25 In addition, patients with frontotemporal dementia (FTD) and ALS26 have shown altered peripheral levels of leptin,which usually happen in the continuous clinical advances of ALS.27