LEP and amyotrophic lateral sclerosis: Some recent reports have demonstratedthat a therapeutic combinationof leptin and pioglitazone as a single-target approach in the treatmentof neurodegenerative conditions may be beneficial in neurologicaldisorders therapy.28,29 Therefore, although ALS has notbeen extensively targeted by the use of therapeutic nanomaterials,30 the use of nanoplatforms for the delivery ofcocktails of drugs, such as a mixture of leptin and pioglitazone,may help to improve the efficiency of this combined therapeutic approach.