DISC1 and Cognitive impairment: To assess the potential network alterations underlying cognitive impairment, we performed single-unit recordings from the mPFC of Disc1-mutant (n = 9) and control mice (n = 7) that were awake in their home cage and analyzed discharge rates of PYRs (n = 720 and 613 in Disc1-mutant and control, respectively) and INTs (n = 104 and 79 in Disc1 and control, respectively; Figure 1, Figure 1—figure supplement 1).