In addition, overexpressing Disc1 carrying a mutation previously associated with schizophrenia-related behavioral impairments (Clapcote et al., 2007) selectively in cortical pyramidal cells (PYRs) results in decreased PV expression in PVIs, suggesting that impaired communication in local cortical circuits might contribute to Disc1-mediated INT dysfunction (Borkowska et al., 2016). Here, DISC1 is linked to schizophrenia.