CRP and obesity due to melanocortin 4 receptor deficiency: According to the subgroup analyses, probiotic and synbiotic supplementation significantly decreased CRP in all subgroups except in studies among patients with normal baseline BMI (18.5–24.9 kg/m2) and individuals with prediabetes (Table 3), showing more potent effects in patients with T2DM (p < 0.001) compared to those with prediabetes (p = 0.07) and individuals with overweight (p < 0.001) and obesity (p = 0.001).