Synaptic pruning has not been confirmed empirically in PBD [52], however, results from this study corroborate those of Patel and colleagues [53], who showed an increased level of N-acetyl aspartate, an indirect marker of synaptogenesis in adolescents with BD, and are in line with those of Seredenina et al. [54] who found reduced expression of NADPH oxidase - a marker of microglial activity - in postmortem brains of individuals with BD. This evidence concerns the gene FMO5 and Behcet disease.