Since RIG-I is a cytosolic PRR that, upon recognition of short viral dsRNA during a viral infection, leads to upregulation of IFN signaling (Matsumiya and Stafforini, 2010), we explored associations between plasma RIG-I levels and related immune measurements, including the mRNA-level and protein-level expression of RIG-I and IFNs, as well as RIG-I and IFN-related modules. This evidence concerns the gene IFNA1 and viral infectious disease.