TCF1 is a known regulator of normal T cell development (Zhao et al., 2021) and has been studied in the context of CD8+ TCF1+ cells in cancers (Burger et al., 2021; Gattinoni et al., 2011; Han et al., 2021; Hanna et al., 2021; Sade-Feldman et al., 2018; Siddiqui et al., 2019). This evidence concerns the gene CD8A and cancer.