We then evaluated whether pharmacological inhibition of WNT signaling similarly promoted CD8+ T cell responses using the PORCN inhibitor LGK974 (blocking all ligand-mediated signaling) and detected similar changes as in the Tcf7 inactivation model, setting the stage to explore WNT inhibition to sensitize pancreatic cancer to immune checkpoint blockade. The gene discussed is TCF7; the disease is pancreatic neoplasm.