Using a genetic approach, we previously inactivated β-catenin in pancreatic epithelial cells in the context of an oncogenic Kras-driven mouse model of pancreatic cancer (KrasLSL-G12D; Ptf1a-Cre, commonly referred to as KC) and showed that epithelial WNT signaling is required for PDA initiation and progression (Zhang et al., 2013). Here, KRAS is linked to familial pancreatic carcinoma.