Using a genetic approach, we previously inactivated β-catenin in pancreatic epithelial cells in the context of an oncogenic Kras-driven mouse model of pancreatic cancer (KrasLSL-G12D; Ptf1a-Cre, commonly referred to as KC) and showed that epithelial WNT signaling is required for PDA initiation and progression (Zhang et al., 2013). This evidence concerns the gene KRAS and pancreatic neoplasm.