IL17A and neoplasm: To establish whether the increase in Th17 cells blunted the effect of PORCNi treatment, given the known protumor effect of Th17 cells and IL-17 (McAllister et al., 2014; Zhang et al., 2018), we repeated the orthotopic syngeneic transplantation experiment with 7940b KPC cells and randomized mice to receive control, PORCNi, anti–IL-17 antibody, or a combination, but observed no change in tumor growth (Fig. S5 H).