The results revealed no change in cell proliferation (Ki67; Fig. 2 E) and fibroblast accumulation or activation (Fig. S2 A) but an increase in tumor cell apoptosis (measured by cleaved caspase 3; Fig. 2 E), indicating that the smaller tumor size in mice with Tcf7 deletion in CD4+ T cells is probably due to enhanced epithelial cell death. This evidence concerns the gene CASP3 and neoplasm.