TCF7 and familial pancreatic carcinoma: We then evaluated whether pharmacological inhibition of WNT signaling similarly promoted CD8+ T cell responses using the PORCN inhibitor LGK974 (blocking all ligand-mediated signaling) and detected similar changes as in the Tcf7 inactivation model, setting the stage to explore WNT inhibition to sensitize pancreatic cancer to immune checkpoint blockade.