SOCS3 and myocardial infarction: 2009). the miR-155 level was significantly raised in rats with MI/RI and miR-155 knockout can ameliorate myocardial infarct and restrain cardiomyocyte apoptosis induced by ischaemia reperfusion (Guo et al. 2019). Furthermore, the increased expression of miR-155 leads to M1 macrophage polarization and inflammatory responses. Suppressor of cytokine signalling 3 (SOCS3), one of the targets of miR-155.miR-155 negatively regulates SOCS3 gene expression by binding to the 3- UTR of SOCS3 mRNAs and then suppresses the expression of the target protein SOCS3 (Henao Agudelo et al. 2017).