In fact, the knockdown of METTL3 in the cytoplasm affects translation in CML and he hypothesized that the translation-promoting effect on methylated mRNAs could represent a general mechanism for cells where METTL3 is localized in the cytoplasm (Ianniello et al., 2021). Here, METTL3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.