LAMB3 and epidermolysis bullosa: For a small number of patients with epidermolysis bullosa who have mutations in the gene encoding the laminin-332 component LAMB3, it has been possible to replace either small (Mavilio et al., 2006) or substantial (Hirsch et al., 2017; Kueckelhaus et al., 2021) proportions of the patients’ skin with cultured, retrovirally transduced epidermal cells expressing the wildtype LAMB3 protein.