Overall, we analyzed the expression patterns of two important determinant proteins of PRAD and COVID-19, TMPRSS2 and CXCL10; scrutinized how the expression levels compare between age groups and explored the functional characteristics of associated genes of TMPRSS2 and CXCL10. The data obtained from our analyses and previous relevant findings suggest that PRAD patients can be placed within the risk group of COVID-19 susceptibility and fatality. The gene discussed is TMPRSS2; the disease is COVID-19.