THBS1 and hepatocellular carcinoma: Furthermore, Xiao et al. [9] showed that exosomes carrying the THBS1 protein that were released from OC tissues might facilitate the conversion of macrophages into tumor-associated macrophages that resemble M1.Myc proto-oncogene protein (MYC) is a well-known transforming gene in many cancers such as breast [58] and lung cancer [59], as well as hepatocellular carcinoma [60].