According to the present results, the has-miR-370-3p was significantly down-regulated in the early-stage OSCC tissues than the healthy controls (p = 0.0000398; Log2 FC = ‒1.84), which may be hypothesized that SPRED3 is overexpressed in the early-stage OSCC tissues, which may be in line with the cancer response. This evidence concerns the gene SPRED3 and cancer.