The effects on anxiety outcomes reported in CB1R inactivation studies (Lafenêtre et al., 2007; Marsicano et al., 2002), the possible association between subjective anxiety and disrupted AEA signaling (Dlugos et al., 2012; Hill et al., 2008), and the potential of CBD to enhance levels of this endogenous ligand of the CB1R (Bisogno et al., 2001) suggest that CBD may be suitable for therapeutic use. Here, CNR1 is linked to Anxiety.