Significantly, the DEPDC5 gene has an important role in the regulation of mTORC1 (Shimobayashi and Hall, 2016), and the combination of a germline TSC2 and somatic DEPDC5 mutation has been described in a TSC patient with intractable epilepsy (Sim et al., 2019). The gene discussed is DEPDC5; the disease is tuberous sclerosis.