TP53 and diabetes mellitus: p53 also responds to changes in energy levels in cells (Okorokov and Milner, 1999) and it inhibits the expression of glucose transporters GLUT1 and GLUT4, thus dampening glycolysis (Schwartzenberg-Bar-Yoseph, Armoni and Karnieli, 2004; Kondoh et al., 2005), also under hypoxic conditions by inducing RRAD (RAS-related associated with diabetes), the Ras-related small GTPase (Zhang et al., 2014).