Andrographolide derivative,3b, ameliorated DSS-induced experimental colitis in mice by inhibiting TLR4-NF-κB and enhancing β-catenin signaling pathway, which could reduce the level and transcription of pro-inflammatory cytokines in serum, while up-regulating β-catenin negatively regulated the immunosuppressive activity of 3b and enhanced TNF-α-mediated cell death (Guo et al., 2019). This evidence concerns the gene TNF and colitis.