The assembly of andrographolide micelles by polyethylene glycol-polythiopropylene block copolymer (PEG-PPS) can effectively downregulate the protein expression levels of IL-6 and MCP-1 in LPS-activated macrophages, and its anti-inflammatory function involves inhibition of the NF-κB pathway; at the same time, it can reduce reactive oxygen species levels to reduce oxidative stress to treat atherosclerosis (Wu et al., 2018a). The gene discussed is NFKB1; the disease is atherosclerosis.