Andrographolide can alleviate atherosclerosis by inducing anti-inflammatory effects and reducing the formation of ROS and foam cells, and its anti-inflammatory function is through the inhibition of the oxidized low-density lipoprotein-induced macrophage proinflammatory molecule monocyte NF-κB signalling pathway, which can downregulate the expression of inflammatory factors such as IL-6 and MCP-1 (Wu et al., 2018b). Here, IL6 is linked to atherosclerosis.