A Study have shown that andrographolide can promote the production of IL-2 and lymphocytes, and IL-2 activates the cytotoxic activity of NK cells, CD8 + T cells and lymphokine-induced killer cells, and produces TNF-α, which increases the cytotoxicity of lymphocytes to cancer cells (Rajagopal et al., 2003). This evidence concerns the gene TNF and cancer.