In streptozotocin-induced Alzheimer’s disease rats, the levels of neuroinflammatory markers (TNF-α, IL-1β, and IL-16) in the andrographolide-treated group were significantly reduced, and inhibition of neuroinflammation was a therapeutically important pathway for neurodegeneration (Patel et al., 2021). This evidence concerns the gene IL1B and early-onset autosomal dominant Alzheimer disease.