Andrographolide attenuates brain injury secondary to intracerebral haemorrhage by inhibiting the nuclear translocation of p65 and the assembly of the NLRP3/ASC/CASP-1 complex and inhibiting the activation of NF-κB and NLPR3 inflammasomes; it reduces microglial activation and neuroinflammation in an intracerebral haemorrhage mouse model, resulting in extremely decreased levels of TNF-α and IL-6 (Li et al., 2018b). The gene discussed is NLRP3; the disease is intracerebral hemorrhage.