IL1B and inflammation: The study indicated that andrographolide alleviated the symptoms of lung inflammation in OVA-induced asthmatic mice through mechanisms such as reducing the total number of leukocytes, macrophages, lymphocytes and neutrophils in BALF and reducing IL-6, IL-4, TNF-α, and IL-1β levels in BALF and serum, which are processes that are related to reactive oxygen species (ROS) scavenging, inhibition of NF-κB signalling, and NLRP3 inflammasome inhibition (Peng et al., 2016a).