These indole derivatives can act on pregnane X receptors (PXR) and AhR and have a certain inhibitory effect on inflammatory diseases such as colitis (Huang W. et al., 2021), arthritis (Rosser et al., 2020), steatohepatitis (Ji et al., 2019; Zhao et al., 2019), ankylosing spondylitis (Shen et al., 2022), and obesity (Su et al., 2022)—consistent with our experimental results. Here, NR1I2 is linked to arthritic joint disease.