These indole derivatives can act on pregnane X receptors (PXR) and AhR and have a certain inhibitory effect on inflammatory diseases such as colitis (Huang W. et al., 2021), arthritis (Rosser et al., 2020), steatohepatitis (Ji et al., 2019; Zhao et al., 2019), ankylosing spondylitis (Shen et al., 2022), and obesity (Su et al., 2022)—consistent with our experimental results. This evidence concerns the gene NR1I2 and obesity due to melanocortin 4 receptor deficiency.