The results showed that MEL down-regulated Bcl-2 and up-regulated cytochrome C (Cyt C), Caspase-3, and Caspase-9 expression, predicting that MEL may rely on the mitochondrial apoptotic pathway to induce tumor injury, and the ratio of apoptosis to necrosis in cancer cells was positively relative to the MEL concentration. Here, MAP2K1 is linked to cancer.