BV treatment decreased the paw volume and arthritis index in RA rats induced by Freund’s complete adjuvant, and showed anti-oxidant, anti-inflammatory, anti-genotoxic, and immunomodulatory effects through decreasing total oxidant status, oxidative stress index, myeloperoxidase (MPO), IL-1β, IL-6, TNF-α, TGF-β1 and mononuclear leukocyte DNA damage levels, and increasing total antioxidant status level (Kocyigit et al., 2019). Here, TNF is linked to arthritic joint disease.