After the combination of BV and Annona muricata fruit, serum levels of matrix metalloproteinase-1 (MMP-1), NF-κB, TNF-α, malondialdehyde (MDA), elevated Caspase-3, superoxide dismutase (SOD), catalase (CAT), and ovarian histopathological changes due to mammary carcinoma were improved in mothers and offspring rats. This evidence concerns the gene NFKB1 and breast carcinoma.