AKT1 and neoplasm: For example, after replacing valine at position 8 and proline at position 14 in MEL with lysine, MEL-pep had stronger ability to resist cell proliferation and inhibit tumor growth, reverse the drug resistance of cells to 5-fluorouracil, inhibit Akt pathway and P-glycoprotein (P-gp) of cells related to the exclusion of foreign bodies (Ke et al., 2018).