BV and MEL induced strongly selective cell death in triple-negative breast carcinoma and human epidermal growth factor receptor 2 (HER2) enriched breast cancer with little effect in routine cells, through interfering with growth factor-dependent receptor tyrosine kinase interactions critical for receptor phosphorylation and activation of phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) signaling. Here, ERBB2 is linked to triple-negative breast carcinoma.