AKT1 and lung cancer: After cisplatin-resistant lung cancer cells A549/DDP were cultured in vitro and treated with MEL, the Warburg effect as well as phosphorylated protein kinase B (Akt) were suppressed; after vaccinating A549/DDP into Balb/c athymic nude mice and treating them via intraperitoneal (i.p.)injection of MEL, their tumor and cell sensitivity to cisplatin was enhanced and tumor size and mass were controlled (Zhang et al., 2021).