AD is characterised by the presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles consisting of hyperphosphorylated tau (Bloom, 2014); these are found in the neocortex (Aβ) and the transentorhinal cortex (tau) in early disease stages but spread throughout the brain as the disease progresses (Braak and Braak, 1991; Thal et al., 2002). Here, MAPT is linked to Alzheimer disease.