OPN1MW and Anxiety: Also, most studies use systemic injections (i.p. or s.c.)to evaluate the anxiolytic effects of CBD (Long et al., 2012; Schiavon et al., 2016; Murphy et al., 2017; Fogaca et al., 2018; Gall et al., 2020; Patra et al., 2020), and it is unknown if the oral route may alter CBD’s effects on anxiety-like behaviour.