However, to date, remedial CBD treatment has not been shown to strongly affect other AD-relevant receptors and molecules in APPxPS1 mice, including brain-derived neurotrophic factor (BDNF), proliferator-activated receptor γ (PPARγ), ionised calcium-binding adaptor molecule 1 (IBA1) and various cytokines (Watt et al., 2020a). The gene discussed is BDNF; the disease is Alzheimer disease.