CMKLR1 and atherosclerosis: RvE1 has been shown to protect against atherogenesis in an animal model of atherosclerosis (Hasturk et al., 2015) and Laguna-Fernandez et al. (Laguna-Fernandez et al., 2018) have demonstrated that targeted deletion of the RvE1 receptor ERV1/Chem23 in a hyperlipidemic animal model was associated with proatherogenic signaling in macrophages, increased oxidized low-density lipoprotein uptake, reduced phagocytosis, and increased atherosclerotic plaque size and necrotic core formation, suggesting that RvE1 might have protective effects during atheroprogression (Salic et al., 2016).