MITF and melanoma: The importance of canonical Wingless-int1 (Wnt) signaling in melanoma initiation is associated chiefly with β-catenin ability to regulate the expression of a wide range of genes of the melanocyte lineage, and its involvement in the regulation of proliferation is probably related to the activation of microphthalmia-associated transcription factor (MITF) expression (Widlund et al., 2002; Larue and Delmas, 2006; Levy et al., 2006; Hoek et al., 2008; Arozarena et al., 2011; Kawakami and Fisher, 2017).