In spite of the fact that various types of cancers, comprising colorectal cancer, melanoma, kidney renal clear cell carcinoma, and lung adenocarcinoma are associated with TRIM28-associated immune responses, there is still a lack of understanding of how TRIM28 contributes to immune infiltration and prognosis in LIHC [15–18]. The gene discussed is TRIM28; the disease is lung adenocarcinoma.