The analysis results showed that the levels of RF_IgA, RF_IgG, and RF_IgM in the RA combined with hypertension group were not significantly different from those in nonhypertensive RA patients (U = 1.750, P = 0.080; U = 1.478, P = 0.139; U = 1.524, P = 0.127). The gene discussed is CD40LG; the disease is rheumatoid arthritis.