COL1A1 and cancer: Among the GO annotation and KEGG pathway enrichment results, the related pathway of extracellular matrix property change has the highest enrichment score in extracellular matrix organization, fibrous collagen trimming, and extracellular matrix structure, indicating that COL collagen family represented by COL1A1 can result in a poor prognosis for patients by participating in the change of ECM properties to promote the generation and development of cancer cells.