Therefore, we examined whether lncRNA-RP11-863P13.3, RP11-576I22.2, and CTD-2171N6.1 may contribute to a poor prognosis in patients with esophageal squamous cell carcinoma by promoting the change of ECM characteristics through the upregulation of Exon 1, Ccl5, COL3A1, and fabricating. Here, COL3A1 is linked to esophageal squamous cell carcinoma.