Wan et al. indicated that LA positivity was an independent associated factor with brain MRI abnormalities (especially lacunae and WMHs) in people without neuropsychiatric symptoms (39), However, in our study, we tested lupus patients with IgG/IgM aβ2-GPI (targeting β2-GPI Domain I) and IgG/IgM aCL and did not further investigate IgA aβ2-GPI (targeting β2-GPI Domain III IV V) or identify β2-GPI-dependent aCL IgG. Here, ACLY is linked to systemic lupus erythematosus.