AABs reduced in PCS/ME/CFS or PCS/non-ME/CFS patients included AABs regulating vascular tone (ADRA2A, ADRB2, BDKRB1, MAS1, CHRM5, CHRNA1, EDNRA, F2R/PAR-1), STAB1 playing a role as scavenger receptor and regulating angiogenesis as well as the inflammatory chemokine receptor CXCR3. The gene discussed is CHRM5; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.