ELAVL1 and hepatocellular carcinoma: Circ00074854 is another tumor promoter in HCC, and circ00074854 knockdown mediates its inhibitory effects by reducing the protein stability of an RNA-binding protein called HuR and exosomes with downregulated circ00074854, which can be delivered to macrophages to inhibit macrophage M2 polarization in vitro (91).