Tumor immunosuppressive microenvironment includes suppressive immune cells such as regulatory T cells (Treg), myeloid-derived suppressor cells (MDSC), immunosuppressive cytokines such as IL-10 and TGF-β, immunosuppressive molecules such as PD-1, and other molecules such as indoleamine dioxygenase 2-3 (IDO1) (7, 48). Here, IL10 is linked to neoplasm.