Mesenchymal Stem Cells (MSCs) are the main components of tumor stroma and have the ability to actively migrate into tumor tissues (72, 73).By making MSCs capable of releasing IL-7 and IL-12 and combining CAR-T cells, researchers found that CAR-T cells could prolong the time of T cells attack on tumors and improve the tumor immunosuppressive microenvironment (74). This evidence concerns the gene IL7 and neoplasm.