Our present study focused on the exploration of ST2+ ILC2, IL-12Rβ2+ ILC1 (non NK) and NKp46+ NK cell populations dynamics and protective immune functional roles in the context of the human lymphatic filaria, B. malayi, using experimental infections of immunocompetent, RAG2-/- and RAG2-/-γc-/- immunodeficient animals and via antibody mediated cell depletions. Here, RAG2 is linked to infection.